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FNP (The Göteborg Forensic Neuropsychiatry Project)

A central aspect of our work has since the 1990s been investigations of neurobiological correlates of aggression. We have in previous studies replicated changes reported by other groups in the blood flow of the frontal and temporal lobes of subjects with aggressive behaviours (Söderström et al., 2000 and 2002). To the best of our knowledge, we are the only group in world to have performed longitudinal brain imaging of violent offenders, even if the study group was very small (Anckarsäter et al., 2007). We were the first to report a relationship between the ratio of the metabolites of dopamine and serotonin in cerebrospinal fluid and aggressive antisociality including reduced capacity for emotional social interaction (Söderström et al., 2001). This finding was then repeated in two new, independent investigations; one of forensic psychiatric investigees and the other of a normal population sample (Söderström et al., 2003; Nilsson et al., 2010).

In two continuation studies (the Surgical Stress Study and the Central Neuroendocrine Adaptation to Surgery study) using chemical markers in cerebrospinal fluid, we have described changes during stress (orthopaedic surgery) in blood-brain barrier permeability and in concentrations of transmitter substances, markers for inflammation and neurodegeneration, and various hormones, such as thyroid hormones and insulin (Anckarsäter R et al., 2007a, 2007b, 2008;submitted and Bromander et al., 2010, 2012). The projects have generated three doctoral dissertations (Henrik Söderström, 2002, Rolf Anckarsäter, 2010, Sara Bromander, 2013). These projects also yield biological samples that are used to understand neurobiological susceptibility factors behind aggression and violent crimes. Another spin-off project is planned in Malmö, using SPECT scans performed on violent offenders during pretrial forensic psychiatric investigations.

In principle, the FNP has now been completed but is followed-up within the UPPRÄTT studies (see different entry).

Principal Investigators: Henrik Anckarsäter & Anders Forsman

Contact Information

Henrik Anckarsäter

Page Manager: Stefan Axelsson|Last update: 8/27/2014

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